So, I got the same problem many of you have but it seems most do not deliver the needed information to fix this issue, so I hope I can help. First, the problem in question: I start the game, it freezes (no response) and then takes about 10-15minutes to load up. In the main menu I can basicially set anything and it seems to work no problem. However, when I start a game, there's tons of textures missing. It basicially looks like they're all standing outside in the rain, everything is black, but the characters. The desk is half invisible too. After the opening cutscene, the game just crashes.
AMD FX(tm)-4100 Quad-Core processor 3.60GHz
Windows 7 64 Bit Ultimate
AMD Radeon HD 7700 HD Series
All my drivers are up-to-date, I reinstalled the game multiple times and verified the game cache. My DirectX is up-to-date too. I tried to disable the Steam layout, I ran it as administrator and I ran it completely out of Steam (using the .exe). Nothing worked. I hope the provided information will help to fix this issue with a patch.